Jacksonville’s medical cannabis scene is thriving in the summer of 2025, with several dispensaries standing out as the most popular choices among patients. As Florida remains a medical-only state following the narrow defeat of the 2024 adult-use amendment, local patients are turning to trusted dispensaries that consistently deliver quality, value, and service.
Trulieve continues to dominate the Jacksonville market with multiple locations, including Arrowhead, Baymeadows, Southside, and Jacksonville Beach. Its extensive menu and wide reach make it one of the most convenient options for patients across the city. Shoppers appreciate regular promotions, such as refer-a-patient discounts, as well as the reliable selection that ranges from premium Khalifa Kush collaborations to affordable Roll One products. This combination of variety, accessibility, and value keeps Trulieve among the busiest dispensaries in the area.
Cookies Jacksonville has carved out its place as a destination for patients seeking top-tier cannabis and exclusive genetics. Located on the Southside, the dispensary is known for its culture-driven brand drops that often result in lines on release days. Patients frequently highlight the potency and flavor of its flower and concentrates, making it a go-to for those looking to treat themselves to premium products like live resin cartridges and high-end eighths.
For patients prioritizing quality above all else, The Flowery’s Baymeadows location has become a standout choice. Known statewide for its boutique indoor flower and limited-run strains, The Flowery maintains high standards from cultivation to packaging. While prices can be higher than other options in Jacksonville, loyal customers say the exceptional terpene profiles and consistent quality justify the cost—especially for connoisseurs seeking small-batch pre-rolls and premium jars.
AYR Cannabis Dispensary, formerly Liberty Health Sciences, is winning over value-conscious patients, especially those in Jacksonville Beach. Known for frequent bundle deals and competitive everyday pricing on cartridges and gummies, AYR also earns praise for its welcoming, patient-friendly environment. Its Philips Highway location offers similar benefits for patients who prefer to shop closer to downtown.
MÜV’s Hendricks Avenue location remains a service leader, consistently earning high marks for its knowledgeable staff. Patients appreciate the personalized recommendations, particularly for concentrates, RSO, and topicals, as well as the steady promotions through the MÜV rewards program. This focus on education and efficiency makes MÜV a favorite for patients seeking expert guidance.
Curaleaf’s San Jose and 103rd Street locations provide a practical option for many Jacksonville patients. While opinions on the brand vary, Curaleaf’s loyal customers cite reliable pickup times, clean and organized stores, and dependable product staples like Select vape cartridges and budget-friendly flower. Regular first-time and loyalty discounts further enhance its appeal as an everyday choice.
Other noteworthy names include VidaCann, which is praised for its friendly staff and consistent flower quality, and Sunnyside, with locations in Riverside and Jacksonville Beach that are popular among edible enthusiasts. While flower reviews for Sunnyside are mixed, its diverse edible lineup keeps it on many patients’ shopping lists.
With patient numbers and product sales continuing to climb in Jacksonville, these dispensaries are proving they can meet demand while building loyal followings. As promotions, product drops, and new openings emerge, the most popular shops may shift—but for summer 2025, these names are leading the way.